AUTOIMMUNE DIAGNOSTICS
Immuno Concepts autoimmune testing,
supported locally in the UK
A complete IFA workflow, from slides to automated processing and digital reading, with UK commercial support, installation, service and training coordinated by DNX Scientific.
Founded in 1979, Immuno Concepts is a US manufacturer specialising in autoimmune diagnostics, with more than four decades supporting laboratories worldwide.
the portfolio
Explore the Immuno Concepts range
Immunofluorescence slides for ANA, ANCA, anti-dsDNA and tissue antibodies, with matched conjugates and controls.
HEp-2 cells overexpressing SS-A/Ro 60 kDa, for ANA screening with enhanced SS-A/Ro detection.
7 · 14 · 18 · 21 well
HEp-2000® ANA
HEp-2 substrate for ANA screening, the gold standard method for ANA detection.
7 · 14 · 18 well
HEp-2 ANA
Crithidia luciliae substrate for specific detection of anti-dsDNA antibodies by kinetoplast staining.
7 · 14 well
nDNA
Ethanol-fixed human neutrophils for ANCA screening and c-ANCA and
p-ANCA pattern identification.
7 · 14 · 18 well
ANCA Ethanol
Formalin-fixed neutrophils to confirm true p-ANCA and distinguish it from ANA interference.
7 · 14 well
ANCA Formalin
Ethanol-fixed neutrophils with the addition of lymphocytes to flag ANA interference.
7 · 14 well
ANCA-L Ethanol
Rodent liver, kidney and stomach sections for AMA, ASMA and APCA detection.
8 well · mouse or rat
HISTOFLUOR® LKS
Primate oesophagus substrate for endomysial antibodies in coeliac disease and dermatitis herpetiformis.
8 well
HISTOFLUOR® EmA
Automated IFA processing and digital slide reading, from sample to report.
Autoimmune FastTrack®
Walk-away IFA processing, from tube to slide.
Image Navigator®
Automated IFA microscopy with the scientist in control.
Features:
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Sample identification: 1D/2D barcode reading of sample tubes and slides
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Automated dilution: efficient dilution algorithm and dispensing onto IFA slides
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Controlled incubation: primary and secondary incubation at ambient temperature or 37 °C
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Precise washing: well-by-well vacuum washing and conjugate addition
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LIS worklists: requests imported from the LIS, with no manual well maps
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Closed-loop titres: titre worklists from Image Navigator® sent straight back to the AFT
Features:
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Automated capture: barcode-verified slides, with four 20× images per well captured hands‑free
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Intelligent sorting: possible negatives grouped for rapid batch review, with sorting levels adjustable for sensitivity or specificity
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Guided pattern review: Pattern Assistant library, optional ICAP AC-code mode and keyboard shortcuts
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Titre management: estimated final dilution suggests endpoints, and titre worklists are created automatically
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Governance and audit: role-based users, audit trail, digital sign-off and kit lot tracking
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Reporting: control, positive, negative and image reports, plus visual inspection lists
Quantitative and semi-quantitative autoantibody ELISAs for connective tissue disease, vasculitis and APS
RELISA® ANA Screen
Qualitative ELISA for antinuclear antibodies in human serum, including anti-dsDNA, Sm, Sm/RNP, SS-A/Ro, SS-B/La and Scl-70. Positive results should be confirmed by IFA on HEp-2 or HEp-2000® substrate.
RELISA® ENA Single-Well Screen
Single-well high-throughput ELISA screen for antibodies to Sm, RNP,
SS-A, SS-B, Scl-70 and Jo-1 in human serum. Identifies ENA-negative samples before specific antibody testing.
RELISA® ENA Multiparameter
A multiparameter ELISA immunoassay for the simultaneous semi-quantitative detection of six autoantibody specificities: SS-A/Ro, SS-B/La, Sm, Sm/RNP, Scl-70, and Jo-1.
RELISA® dsDNA
Semi-quantitative ELISA for the detection of anti-dsDNA antibodies in human serum. Aids the diagnosis of systemic lupus erythematosus.
RELISA® Cardiolipin IgG & IgM
Quantitative ELISA for IgG and IgM anticardiolipin antibodies in human serum, using isotype-specific conjugates. Aids the evaluation of antiphospholipid syndrome.
RELISA® MPO / PR3
Quantitative ELISA for anti-MPO and anti-PR3 antibodies in human serum. Confirms ANCA specificity after IFA screening in suspected
ANCA-associated vasculitis.
Reference slide for daily quality control of fluorescence microscope performance.
FITC-QC Slide™
FITC-labelled microbead slide with five graded wells (±, 1+, 2+, 3+ and 4+), calibrated by flow cytometry. Provides a reference for fluorescence intensity grading and confirms microscope performance before each run.
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Calibrated intensity standards: flow cytometry-calibrated beads across the full grading range, aligned with CLSI I/LA2 guidance
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Pre-run performance check: detects loss of sensitivity from ageing light sources or misaligned optics
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Quick to use: no set-up or extra equipment, just your existing fluorescence microscope
Ready-to-use positive, negative and titratable controls for confident IFA pattern interpretation.
ANA Controls
Positive, negative and titratable controls for HEp-2 and HEp-2000® ANA testing, including optional controls for less common patterns.
Homogeneous · Speckled · Nucleolar · Centromere · SS-A · Scl-70 · PCNA · Golgi · Mitochondrial
ANCA Controls
Positive, negative and titratable controls for c-ANCA and p-ANCA pattern identification on ethanol- and formalin-fixed neutrophils.
c-ANCA (PR3) · p-ANCA (MPO) · Negative
nDNA Controls
Positive, negative and titratable controls for anti-dsDNA testing on Crithidia luciliae.
Positive · Titratable · Negative
Tissue Antibody Controls
Positive, negative and titratable controls for HISTOFLUOR® LKS and EmA tissue substrates.
AMA · ASMA · APCA · EmA · Negative
Ongoing ANA interpretation training using real patient samples.
PSITS – Patient Sample Interpretive Training Series
An annual training programme for ANA laboratories, using characterised patient sera to build confidence in pattern interpretation and follow-up testing decisions.
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Real patient samples: four sets of patient sera supplied at the start of each year, plus additional online image cases
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Peer benchmarking: results compared against consensus findings, other methods and other laboratories
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Clinical context: each case comes with a brief clinical summary and reference pattern images
Receive
Four sets of patient serum samples and two photographic sets with clinical notes
01
Interpret
Test with your routine ANA method and decide whether follow-up testing is indicated
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Submit online
Enter or amend results on PSITS Online with your subscriber login
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Compare and learn
Consensus results by method group, clinical diagnosis and ANA pattern images